Gregory Pincus had success testing a hormonal compound in animals; to pursue oral hormone contraceptive for humans, he needed an experienced clinician. Rock, who had used hormone treatments to successfully halt ovulation in his infertility patients in 1952, was his choice. The first field trials using the Searle-manufactured hormone were established in San Juan, Puerto Rico in 1956. Rock, Pincus, and Celso-Ramon Garica wrote the protocols for the study; Edris Rice-Wray was selected to manage the project on a daily basis. The field trials expanded over the years and involved additional sites in Puerto Rico and Haiti. Clarence J. Gamble, with his associate Adeline Pendleton Satterwaite, followed suit and formed trials in Puerto Rico based on the previous work of Rock, Pincus and Garcia. Protocols regarding potential participants and methods for each pill trial
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